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pandora necklaces Inconsistency between direct and indirect comparisons was not significant.Conclusions Although limited in quantity https://www.jewelleryflq679.top, existing randomised trial evidence on exercise interventions suggests that exercise and many drug interventions are often potentially similar in terms of their mortality benefits in the secondary prevention of coronary heart disease pandora charms, rehabilitation after stroke, treatment of heart failure, and prevention of diabetes.IntroductionPhysical activity has well documented health benefits.1 Population level cohort studies have shown that people who exercise enjoy a higher quality of life and improved health status compared with those with sedentary behaviours, with subsequent reductions in their risk of adverse outcomes such as admissions to hospital. Randomised controlled trials have shown similarly favourable findings in arthritis,2 cancer,3 4 diabetes,5 heart disease,6 and respiratory illnesses,7 among other chronic conditions.8 9 Large scale observational studies have also established a clear association between exercise and all cause mortality.10 11 12 Given the overwhelming evidence in support of the health benefits of exercise,13 the Global Burden of Disease study has recently ranked physical inactivity as the fifth leading cause of disease burden in western Europe, and as one of the top modifiable risk factors along with smoking.14Despite recent calls to encourage physical activity as a strategy to ward off the emerging burden of chronic conditions, including heart disease and diabetes,15 population level physical activity measures are discouraging. In the United Kingdom, only 14% of adults exercise regularly, with roughly one third of adults in England meeting recommended levels of physical activity.16 In contrast, utilisation rates of prescription drugs continue to rise sharply, increasing to an average of 17.7 prescriptions for every person in England in 2010, compared with 11.2 in 2000.17Abundant evidence from randomised controlled trials shows the mortality benefits of certain drugs such as simvastatin in the secondary prevention of cardiovascular disease,18 which is the most widely prescribed drug in the United Kingdom. pandora necklaces
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